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SkinCeuticals A.G.E. Interrupter

SkinCeuticals A.G.E. Interrupter

Item #:03-0110
Price:$156.00
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50 mL

Mature skin treatment to help reverse erosion of elasticity and firmness caused by advanced glycation end products

One main cause of visible aging is glycation, which occurs when excess glucose molecules bind to collagen and elastin fibers and prompt the formation of advanced glycation end-products (A.G.E.s) that lead to severe skin wrinkling. A.G.E. Interrupter is a unique treatment formulated with 4% blueberry extract, 30% Proxylane™ and 0.2% phytosphingosine to help prevent the glycation process and correct severe signs of aging in mature skin.

•Blueberry extract slows down the process of advanced glycation end-product (A.G.E.) formation, preventing collagen and elastin fibers from becoming rigid

•Proxylane™ stimulates GAG synthesis, restoring water and nutrients to the dermal-epidermal junction

•Phytosphingosine helps protect the skin’s barrier to alleviate discomfort associated with dry, aging skin

In a clinical study using fluorescence measurements, blueberry extract in the presence of ribose as a reducing sugar had a similar dose response to positive control aminoguanidine, a potent glycation inhibitor. In addition, in reconstructed skin containing collagen modified by glycation, treatment with blueberry extract diminished CML antibodies (one of the A.G.E.s found in chronologically aged skin in-vivo), and returned previously over-expressed biomarkers to a normal pattern of distribution. These results indicate a return to skin’s normal morphological structure.

Blueberry extract is both an antioxidant and anti-glycation ingredient that inhibits advanced glycation end-products (A.G.E.s) while preventing further oxidation from occurring. Proxylane rebuilds the support structure that degrades as a direct result of intrinsic aging and efficiently improves anchorage of the skin’s upper layers onto the dermis to increase elasticity and thickness. Phytosphingosine protects the skin’s barrier, while rich emollients hydrate dry, cracking skin.

Innovation 1

Our advanced research group evaluated several different blueberry extracts, screening each for anti-glycation activity, selecting the particular extract in A.G.E. Interrupter for its potent anti-glycation activity, compatibility with other actives in the formula and efficiency in skin. We currently have two patents pending with this specific ingredient, including one for anti- glycation and another for MMP inhibition. Four percent of the extract was the level found to be most effective in clinical trials.


Apply once or twice daily to face, neck, and chest

Professional Recommendation is Advised


Key Ingredient 1

Blueberry extract: Inhibits the glycation of collagen, normalizes MMP-1 production preventing degradation of healthy collagen types IV and VII and stimulates procollagen I and III, which are essential components of young-looking skin.

Key Ingredient 2

Proxylane: This innovative ingredient stimulates the synthesis of glycosaminoglycans (GAGs) in the skin. GAGs help repair damage that directly impacts the surface of the skin.

Key Ingredient 3

Phytosphingosine: Reinforces the skin’s barrier by promoting the synthesis of lipids necessary for barrier function.



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